Unexplained Weight Loss: When to Seek Evaluation

Unintentional weight loss may warrant evaluation. Learn the lab tests clinicians commonly consider as part of a workup.

Unintentional weight loss is weight loss that occurs without a deliberate change in diet or activity. It is a non-specific symptom that may warrant evaluation, particularly when significant or accompanied by other symptoms.

Lab tests clinicians may consider

Depending on the clinical picture, tests that may help in the evaluation include:

• Complete blood count
• Comprehensive metabolic panel
• Kidney function panel
• Liver function tests
• Thyroid function tests
• Inflammatory markers

When to seek review

Unintentional weight loss of more than around 5% of body weight, or any weight loss accompanied by symptoms such as persistent pain, blood in the stool, or night sweats, may warrant prompt medical review.